(Tyr5,D-Trp6.8.9,Lys-NH2¹?)-Neurokinin A (4-10) structure
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Common Name | (Tyr5,D-Trp6.8.9,Lys-NH2¹?)-Neurokinin A (4-10) | ||
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CAS Number | 135306-85-3 | Molecular Weight | 1081.22000 | |
Density | 1.361 g/cm3 | Boiling Point | 1555.4?C at 760 mmHg | |
Molecular Formula | C57H68N12O10 | Melting Point | N/A | |
MSDS | USA | Flash Point | 894.5?C |
Use of (Tyr5,D-Trp6.8.9,Lys-NH2¹?)-Neurokinin A (4-10)Men 10376 is a selective tachykinin NK-2 receptor antagonist, with a Ki of 4.4 μM for rat small intestine NK-2 receptor. |
Name | asp-tyr-d-trp-val-d-trp-d-trp-lys-nh2 |
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Synonym | More Synonyms |
Description | Men 10376 is a selective tachykinin NK-2 receptor antagonist, with a Ki of 4.4 μM for rat small intestine NK-2 receptor. |
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Related Catalog | |
Target |
Ki: 4.4 μM (NK-2 receptor, rat small intestine)[1] |
In Vitro | Men 10376 is a selective tachykinin NK-2 receptor, with a Ki of 4.4 μM, and shows low selectivity for NK-1 and NK-3 receptors (Ki, >10 μM)[1]. Men 10376 shows pA2s of 5.66 and 8.08 for NK-1 (guinea-pig ileum) and NK-2 receptors (endothelium-deprived rabbit pulmonary artery). Men 10376 shows no effect on NK-3 receptor (Ki, >10 μM)[2]. |
In Vivo | Men 10376 (1 and 3 μmol/kg) antagonizes increase in bladder motility produced by the NK-2 receptor agonist in rats[2]. |
References |
[1]. Quartara L, et al. N-terminal truncated analogs of men 10376 as tachykinin NK-2 receptor antagonists. Life Sci. 1992;51(25):1929-36. [2]. Maggi CA, et al. In vivo evidence for tachykininergic transmission using a new NK-2 receptor-selective antagonist, MEN 10,376. J Pharmacol Exp Ther. 1991 Jun;257(3):1172-8. |
Density | 1.361 g/cm3 |
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Boiling Point | 1555.4?C at 760 mmHg |
Molecular Formula | C57H68N12O10 |
Molecular Weight | 1081.22000 |
Flash Point | 894.5?C |
Exact Mass | 1080.52000 |
PSA | 374.63000 |
LogP | 6.53410 |
Vapour Pressure | 0mmHg at 25°C |
Index of Refraction | 1.672 |
Storage condition | -20°C |
Water Solubility | Insuluble (2.3E-3 g/L) (25 ?C) |
Hazard Codes | N |
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RIDADR | NONH for all modes of transport |
WGK Germany | 3.0 |
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L-Asp-L-Tyr-D-Trp-L-Val-D-Trp-D-Trp-L-Lys-NH2 |
NK2 TACHYKININ RECEPT |
M.W. 1081.24 C57H68N12O10 |
(TYR5,D-TRP6·8·9,LYS-NH210)-NEUROKININ A (4-10) |
Men 10376 |