cc彩球网


cc彩球网:(Tyr5,D-Trp6.8.9,Lys-NH2¹?)-Neurokinin A (4-10)

Modify Date: 2024-01-02 08:46:49

(Tyr5,D-Trp6.8.9,Lys-NH2¹?)-Neurokinin A (4-10) Structure
(Tyr5,D-Trp6.8.9,Lys-NH2¹?)-Neurokinin A (4-10) structure
Common Name (Tyr5,D-Trp6.8.9,Lys-NH2¹?)-Neurokinin A (4-10)
CAS Number 135306-85-3 Molecular Weight 1081.22000
Density 1.361 g/cm3 Boiling Point 1555.4?C at 760 mmHg
Molecular Formula C57H68N12O10 Melting Point N/A
MSDS USA Flash Point 894.5?C

 Use of (Tyr5,D-Trp6.8.9,Lys-NH2¹?)-Neurokinin A (4-10)


Men 10376 is a selective tachykinin NK-2 receptor antagonist, with a Ki of 4.4 μM for rat small intestine NK-2 receptor.

 Names

Name asp-tyr-d-trp-val-d-trp-d-trp-lys-nh2
Synonym More Synonyms

  Biological Activity

Description Men 10376 is a selective tachykinin NK-2 receptor antagonist, with a Ki of 4.4 μM for rat small intestine NK-2 receptor.
Related Catalog
Target

Ki: 4.4 μM (NK-2 receptor, rat small intestine)[1]

In Vitro Men 10376 is a selective tachykinin NK-2 receptor, with a Ki of 4.4 μM, and shows low selectivity for NK-1 and NK-3 receptors (Ki, >10 μM)[1]. Men 10376 shows pA2s of 5.66 and 8.08 for NK-1 (guinea-pig ileum) and NK-2 receptors (endothelium-deprived rabbit pulmonary artery). Men 10376 shows no effect on NK-3 receptor (Ki, >10 μM)[2].
In Vivo Men 10376 (1 and 3 μmol/kg) antagonizes increase in bladder motility produced by the NK-2 receptor agonist in rats[2].
References

[1]. Quartara L, et al. N-terminal truncated analogs of men 10376 as tachykinin NK-2 receptor antagonists. Life Sci. 1992;51(25):1929-36.

[2]. Maggi CA, et al. In vivo evidence for tachykininergic transmission using a new NK-2 receptor-selective antagonist, MEN 10,376. J Pharmacol Exp Ther. 1991 Jun;257(3):1172-8.

 Chemical & Physical Properties

Density 1.361 g/cm3
Boiling Point 1555.4?C at 760 mmHg
Molecular Formula C57H68N12O10
Molecular Weight 1081.22000
Flash Point 894.5?C
Exact Mass 1080.52000
PSA 374.63000
LogP 6.53410
Vapour Pressure 0mmHg at 25°C
Index of Refraction 1.672
Storage condition -20°C
Water Solubility Insuluble (2.3E-3 g/L) (25 ?C)

 Safety Information

Hazard Codes N
RIDADR NONH for all modes of transport
WGK Germany 3.0

 Articles29

More Articles
Effects of substance P on identified neurons of the rat dorsal motor nucleus of the vagus.

Am. J. Physiol. Gastrointest. Liver Physiol. 281(1) , G164-72, (2001)

Previous evidence suggests that substance P (SP) activates subpopulations of neurons within the dorsal motor nucleus of the vagus (DMV). In this study we aimed at identifying these subpopulations in r...

Neurokinin receptors modulate the impact of uncontrollable stimulation on adaptive spinal plasticity.

Behav. Neurosci. 121(5) , 1082-94, (2007)

Previous research has demonstrated that spinally transected rats can acquire a prolonged flexion response to prevent the delivery of shock. However, rats that receive shock irrespective of leg positio...

Intrathecal administration of neurokinin 1 and neurokinin 2 receptor antagonists undermines the savings effect in spinal rats seen in an instrumental learning paradigm.

Behav. Neurosci. 121(1) , 186-99, (2007)

Research has demonstrated that the isolated spinal cord is capable of modifying its behavior in response to changes in environmental stimuli. Previous studies have shown that rats with complete thorac...

 Synonyms

L-Asp-L-Tyr-D-Trp-L-Val-D-Trp-D-Trp-L-Lys-NH2
NK2 TACHYKININ RECEPT
M.W. 1081.24 C57H68N12O10
(TYR5,D-TRP6·8·9,LYS-NH210)-NEUROKININ A (4-10)
Men 10376
Top Suppliers:I want be here


Get all suppliers and price by the below link:

(Tyr5,D-Trp6.8.9,Lys-NH2¹?)-Neurokinin A (4-10) suppliers


Price: ¥1950/1?mg

Reference only. check more (Tyr5,D-Trp6.8.9,Lys-NH2¹?)-Neurokinin A (4-10) price


cc彩球网(中国)IOS/安卓版手机APP官网下载V3.95.65