抗菌肽 B结构式
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常用名 | 抗菌肽 B | 英文名 | Cecropin B |
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CAS号 | 80451-05-4 | 分子量 | 3834.67 | |
密度 | N/A | 沸点 | N/A | |
分子式 | C176H302N52O41S | 熔点 | N/A | |
MSDS | 美版 | 闪点 | N/A |
抗菌肽 B用途Cecropin B 有着高水平的抗菌活性,且是一种有价值的肽类抗菌素。 |
中文名 | 抗菌肽 B |
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英文名 | Cecropin B |
英文别名 | 更多 |
描述 | Cecropin B 有着高水平的抗菌活性,且是一种有价值的肽类抗菌素。 |
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相关类别 | |
体外研究 | Cecropin B-诱导NF-κB活化通过破坏PXR /类视黄醇X受体α(RXR-α)复合物与DNA序列的结合在抑制CYP3A29中起关键cc彩球网。 Cecropin B通过与TLRs 2和4相互cc彩球网激活猪肝细胞,TLRs 2和4调节NF-κB介导的信号通路[1]。 |
体内研究 | 伤口湿润,C组渗出较多,而其他组则干燥,无明显渗出。每组中大多数小鼠的体温升高,但每组中白细胞的数量在手术后降低。 A组肌肉细菌数量明显低于M组和C组。 C组4个PID后存活小鼠的数量明显少于A组和M组(P <0.05)[2]。 |
动物实验 | 小鼠[1]将30只ICR小鼠纳入研究,并通过切除1cm×1cm面积的背皮全层来复制铜绿假单胞菌感染模型。然后将它们随机分为C组(对照组,n = 10,在伤后3小时(PIH)用等压生理盐水湿敷),M(在3 PIH下用100g / L的磺胺类药物进行亲水性压缩),A(湿敷)在3个PIH)组中的1 000 mg / L天蚕素B。在损伤前和伤后4天测定各组体温和血象的变化[2]。 |
参考文献 |
[2]. Ren HT et al. [The antibacterial effect of cecropin B on pseudomonas aeruginosa infection of wounds in mice].Zhonghua Shao Shang Za Zhi. 2006 Dec;22(6):445-7. |
分子式 | C176H302N52O41S |
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分子量 | 3834.67 |
储存条件 | -20°C |
个人防护装备 | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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:β (欧洲) | Xi |
危险品运输编码 | NONH for all modes of transport |
WGK德国 | 3.0 |
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H-Lys-Trp-Lys-Val-Phe-Lys-Lys-Ile-Glu-Lys-Met-Gly-Arg-Asn-Ile-Arg-Asn-Gly-Ile-Val-Lys-Ala-Gly-Pro-Ala-Ile-Ala-Val-Leu-Gly-Glu-Ala-Lys-Ala-Leu-NH2 |
KWKVFKKIEKMGRNIRNGIVKAGPAIAVLGEAKAL-NH2 |