cc彩球网:异槲皮苷

更新时间:2024-01-02 18:34:25

异槲皮苷结构式
异槲皮苷结构式
品牌特惠专场
常用名 异槲皮苷 英文名 Isoquercitrin
CAS号 21637-25-2 分子量 464.376
密度 1.9±0.1 g/cm3 沸点 872.6±65.0 °C at 760 mmHg
分子式 C21H20O12 熔点 225-227°
MSDS N/A 闪点 307.5±27.8 °C

 异槲皮苷用途


Isoquercitrin 是一种有效的抗氧化剂和嗜酸性炎症抑制剂。

 异槲皮苷名称

中文名 异槲皮苷
英文名 quercetin 3-O-β-D-glucofuranoside
中文别名 罗布麻甲素 | 异栎素 | 槲皮素-3-葡萄糖甙 | 槲皮素-3-O-葡萄糖苷
英文别名 更多

 异槲皮苷生物活性

描述 Isoquercitrin 是一种有效的抗氧化剂和嗜酸性炎症抑制剂。
相关类别
体外研究 异槲皮苷广泛存在于植物中.7种化合物中的10μM异槲皮苷部分但显着地减弱了H2O2对RGC-5细胞的负面影响,因为H2O2存在时细胞的存活率从大约63%增加到83%和90%分别为10和50μM时的%。实际上,50μM等槲皮苷作为神经保护剂比相同浓度的EGCG更有效[1]。
体内研究 在接受异槲皮苷或槲皮素的动物中,BALF,血液和肺实质中的嗜酸性粒细胞计数较低。血液中的中性粒细胞计数和肺匀浆中的IL-5水平仅在Isoquercitrin处理的小鼠中较低。没有观察到单核细胞数量的改变[2]。
动物实验 免疫小鼠[2] BALB / c小鼠(卵清蛋白/氢氧化铝,sc),然后进行两次鼻内卵清蛋白攻击。从第一次免疫后第18天到第22天,小鼠每天接受异槲皮苷(15mg / kg)或槲皮素(10mg / kg)的强饲。施用地塞米松(1mg / kg,sc)作为阳性对照。在最后一次卵清蛋白激发后24小时,在支气管肺泡灌洗液(BALF),血液和肺实质中分析白细胞。白细胞介素-5(IL-5)在BALF和肺匀浆中进行分析[2]。
参考文献

[1]. Jung SH, et al. Isoquercitrin is the most effective antioxidant in the plant Thuja orientalis and able to counteract oxidative-induced damage to a transformed cell line (RGC-5 cells). Neurochem Int. 2010 Dec;57(7):713-21.

[2]. Rogerio AP, et al. Anti-inflammatory activity of quercetin and isoquercitrin in experimental murine allergic asthma. Inflamm Res. 2007 Oct;56(10):402-8.

 异槲皮苷物理化学性质

密度 1.9±0.1 g/cm3
沸点 872.6±65.0 °C at 760 mmHg
熔点 225-227°
分子式 C21H20O12
分子量 464.376
闪点 307.5±27.8 °C
精确质量 464.095490
PSA 210.51000
LogP 1.75
蒸汽压 0.0±0.3 mmHg at 25°C
折射率 1.803
储存条件 ?20°C

 异槲皮苷毒性和生态

 异槲皮苷安全信息

安全声明 (欧洲) 24/25
危险品运输编码 UN 2811
WGK德国 3
RTECS号 LK8960000

 异槲皮苷上下游产品

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 异槲皮苷文献28

更多文献
Isoquercitrin provides better bioavailability than quercetin: comparison of quercetin metabolites in body tissue and brain sections after six days administration of isoquercitrin and quercetin.

Pharmazie 67(12) , 991-6, (2012)

In the present study, over a period of 8 days 12 mg/kg/d quercetin aglycone and 18 mg/kg/d isoquercitrin were orally given to rats, respectively. Four hours after administration, plasma samples were t...

A sensitive LC-MS/MS method for simultaneous determination of six flavonoids in rat plasma: application to a pharmacokinetic study of total flavonoids from mulberry leaves.

J. Pharm. Biomed. Anal. 84 , 189-95, (2013)

A simple and sensitive LC-MS/MS method has been developed and validated for the determination of rutin, isoquercitrin, astragalin, quercetin, kaempferol and isorhamnetin in rat plasma using naringin a...

Complete 1H NMR spectral analysis of ten chemical markers of Ginkgo biloba.

Magn. Reson. Chem. 50(8) , 569-75, (2012)

The complete and unambiguous (1)H NMR assignments of ten marker constituents of Ginkgo biloba are described. The comprehensive (1)H NMR profiles (fingerprints) of ginkgolide A, ginkgolide B, ginkgolid...

 异槲皮苷英文别名

Quercetin 3-O-β-glucoside
trifoliin
2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl β-D-glucofuranoside
quercetin 3-O-β-D-glucopyranoside
Quercetin 3β-O-glucoside
4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-3-(β-D-glucofuranosyloxy)-5,7-dihydroxy-
4H-1-Benzopyran-4-one, 2-(3,4-dihydroxy-phenyl)-3-(β-D-glucofuranosyloxy)-5,7-dihydroxy-
Quercetin 3-β-glucoside
Quercetin 3-O-glucofuranoside
2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl β-D-glucopyranoside
Isopseudopsoralen
isopseudopsoralene
Quercetin 3-β-D-glucoside
quercetin-3-glucoside
3-O-β-D-Glucopyranosylquercetin
Quercetin glucoside
Isoquercitroside
Quercetin-3-O-β-D-glucoside
isopseudosporalen
Quercetin-3-O-β-glucopyranoside
Isoquercetrin
Quercetin 3-O-glucoside
Quercetin 3-D-glucoside
Isoquercitrin
isoquercetin
quercetin 3-O-β-D-glucoside
Hirsutrin
isotrifoliin
4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-3-(β-D-glucopyranosyloxy)-5,7-dihydroxy-
3,3',4',5,7-Pentahydroxyflavone 3-b-D-glucofuranoside
Quercetin-3-β-glucopyranoside
quercetin 3-O-beta-D-glucofuranoside
Quercetin-3-O-glucoside
Quercetin 3-β-O-glucoside
2-(3,4-Dihydroxyphenyl)-3-(b-D-glucofuranosyloxy)-5,7-dihydroxy-4H-1-benzopyran-4-one
Quercetin 3-O-glucopyranoside
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