异槲皮苷结构式
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常用名 | 异槲皮苷 | 英文名 | Isoquercitrin |
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CAS号 | 21637-25-2 | 分子量 | 464.376 | |
密度 | 1.9±0.1 g/cm3 | 沸点 | 872.6±65.0 °C at 760 mmHg | |
分子式 | C21H20O12 | 熔点 | 225-227° | |
MSDS | N/A | 闪点 | 307.5±27.8 °C |
异槲皮苷用途Isoquercitrin 是一种有效的抗氧化剂和嗜酸性炎症抑制剂。 |
中文名 | 异槲皮苷 |
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英文名 | quercetin 3-O-β-D-glucofuranoside |
中文别名 | 罗布麻甲素 | 异栎素 | 槲皮素-3-葡萄糖甙 | 槲皮素-3-O-葡萄糖苷 |
英文别名 | 更多 |
描述 | Isoquercitrin 是一种有效的抗氧化剂和嗜酸性炎症抑制剂。 |
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相关类别 | |
体外研究 | 异槲皮苷广泛存在于植物中.7种化合物中的10μM异槲皮苷部分但显着地减弱了H2O2对RGC-5细胞的负面影响,因为H2O2存在时细胞的存活率从大约63%增加到83%和90%分别为10和50μM时的%。实际上,50μM等槲皮苷作为神经保护剂比相同浓度的EGCG更有效[1]。 |
体内研究 | 在接受异槲皮苷或槲皮素的动物中,BALF,血液和肺实质中的嗜酸性粒细胞计数较低。血液中的中性粒细胞计数和肺匀浆中的IL-5水平仅在Isoquercitrin处理的小鼠中较低。没有观察到单核细胞数量的改变[2]。 |
动物实验 | 免疫小鼠[2] BALB / c小鼠(卵清蛋白/氢氧化铝,sc),然后进行两次鼻内卵清蛋白攻击。从第一次免疫后第18天到第22天,小鼠每天接受异槲皮苷(15mg / kg)或槲皮素(10mg / kg)的强饲。施用地塞米松(1mg / kg,sc)作为阳性对照。在最后一次卵清蛋白激发后24小时,在支气管肺泡灌洗液(BALF),血液和肺实质中分析白细胞。白细胞介素-5(IL-5)在BALF和肺匀浆中进行分析[2]。 |
参考文献 |
[1]. Jung SH, et al. Isoquercitrin is the most effective antioxidant in the plant Thuja orientalis and able to counteract oxidative-induced damage to a transformed cell line (RGC-5 cells). Neurochem Int. 2010 Dec;57(7):713-21. [2]. Rogerio AP, et al. Anti-inflammatory activity of quercetin and isoquercitrin in experimental murine allergic asthma. Inflamm Res. 2007 Oct;56(10):402-8. |
密度 | 1.9±0.1 g/cm3 |
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沸点 | 872.6±65.0 °C at 760 mmHg |
熔点 | 225-227° |
分子式 | C21H20O12 |
分子量 | 464.376 |
闪点 | 307.5±27.8 °C |
精确质量 | 464.095490 |
PSA | 210.51000 |
LogP | 1.75 |
蒸汽压 | 0.0±0.3 mmHg at 25°C |
折射率 | 1.803 |
储存条件 | ?20°C |
安全声明 (欧洲) | 24/25 |
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危险品运输编码 | UN 2811 |
WGK德国 | 3 |
RTECS号 | LK8960000 |
异槲皮苷上游产品 0 | |
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异槲皮苷下游产品 2 | |
Isoquercitrin provides better bioavailability than quercetin: comparison of quercetin metabolites in body tissue and brain sections after six days administration of isoquercitrin and quercetin.
Pharmazie 67(12) , 991-6, (2012) In the present study, over a period of 8 days 12 mg/kg/d quercetin aglycone and 18 mg/kg/d isoquercitrin were orally given to rats, respectively. Four hours after administration, plasma samples were t... |
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A sensitive LC-MS/MS method for simultaneous determination of six flavonoids in rat plasma: application to a pharmacokinetic study of total flavonoids from mulberry leaves.
J. Pharm. Biomed. Anal. 84 , 189-95, (2013) A simple and sensitive LC-MS/MS method has been developed and validated for the determination of rutin, isoquercitrin, astragalin, quercetin, kaempferol and isorhamnetin in rat plasma using naringin a... |
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Complete 1H NMR spectral analysis of ten chemical markers of Ginkgo biloba.
Magn. Reson. Chem. 50(8) , 569-75, (2012) The complete and unambiguous (1)H NMR assignments of ten marker constituents of Ginkgo biloba are described. The comprehensive (1)H NMR profiles (fingerprints) of ginkgolide A, ginkgolide B, ginkgolid... |
Quercetin 3-O-β-glucoside |
trifoliin |
2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl β-D-glucofuranoside |
quercetin 3-O-β-D-glucopyranoside |
Quercetin 3β-O-glucoside |
4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-3-(β-D-glucofuranosyloxy)-5,7-dihydroxy- |
4H-1-Benzopyran-4-one, 2-(3,4-dihydroxy-phenyl)-3-(β-D-glucofuranosyloxy)-5,7-dihydroxy- |
Quercetin 3-β-glucoside |
Quercetin 3-O-glucofuranoside |
2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl β-D-glucopyranoside |
Isopseudopsoralen |
isopseudopsoralene |
Quercetin 3-β-D-glucoside |
quercetin-3-glucoside |
3-O-β-D-Glucopyranosylquercetin |
Quercetin glucoside |
Isoquercitroside |
Quercetin-3-O-β-D-glucoside |
isopseudosporalen |
Quercetin-3-O-β-glucopyranoside |
Isoquercetrin |
Quercetin 3-O-glucoside |
Quercetin 3-D-glucoside |
Isoquercitrin |
isoquercetin |
quercetin 3-O-β-D-glucoside |
Hirsutrin |
isotrifoliin |
4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-3-(β-D-glucopyranosyloxy)-5,7-dihydroxy- |
3,3',4',5,7-Pentahydroxyflavone 3-b-D-glucofuranoside |
Quercetin-3-β-glucopyranoside |
quercetin 3-O-beta-D-glucofuranoside |
Quercetin-3-O-glucoside |
Quercetin 3-β-O-glucoside |
2-(3,4-Dihydroxyphenyl)-3-(b-D-glucofuranosyloxy)-5,7-dihydroxy-4H-1-benzopyran-4-one |
Quercetin 3-O-glucopyranoside |