艾塞那肽结构式
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常用名 | 艾塞那肽 | 英文名 | Exendin-3 trifluoroacetate salt |
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CAS号 | 130357-25-4 | 分子量 | 4202.57 | |
密度 | N/A | 沸点 | N/A | |
分子式 | C184H282N50O61S | 熔点 | N/A | |
MSDS | 美版 | 闪点 | N/A |
艾塞那肽用途Exendin-3是从吉拉怪兽蜥蜴 Heloderma horridurn 毒液分离的生物活性肽。 |
中文名 | 艾塞那肽 |
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英文名 | EXENDIN-3 |
英文别名 | 更多 |
描述 | Exendin-3是从吉拉怪兽蜥蜴 Heloderma horridurn 毒液分离的生物活性肽。 |
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相关类别 | |
靶点 |
VIP receptor, putative exendin receptor[1] |
体外研究 | Exendin-3与豚鼠胰腺腺泡中的至少两种受体相互cc彩球网;在高浓度(> 100nM)下,肽与VIP受体相互cc彩球网,从而引起cAMP的大量增加和刺激淀粉酶释放;在较低浓度(0.1-3nM)下,肽与推定的毒蜥外泌肽受体相互cc彩球网,从而导致未确定功能的cAMP的较小增加[1]。 |
激酶实验 | 用VIP,促胰液素或毒蜥外泌肽-3观察到增加浓度的两种VIP受体拮抗剂对淀粉酶释放增加的影响。将雄性Hartley豚鼠Acini与VIP(1nM),促胰液素(1μM)或Exendin-3(1μM)在37℃温育30分钟,单独或与指定浓度的[AcTyr,D-Phe]组合] GRF 1-29酰胺(实心符号)或[4-Cl-D-Phe,Leu] VIP(空心符号)[1]。 |
参考文献 |
[1]. Raufman JP, et al. Exendin-3, a novel peptide from Heloderma horridum venom, interacts with vasoactive intestinal peptide receptors and a newly described receptor on dispersed acini from guinea pig pancreas. Description of exendin-3(9-39) amide, a specific exendin receptor antagonist. J Biol Chem. 1991 Feb 15;266(5):2897-902. |
分子式 | C184H282N50O61S |
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分子量 | 4202.57 |
储存条件 | 密封、在 -20ºC下保存 |
更多 | 1. 性状:未确定 2. 密度(g/mL,20℃):未确定 3. 相对蒸汽密度(g/mL,空气=1):未确定 4. 熔点(ºC):未确定 5. 沸点(ºC,常压):未确定 6. 沸点(ºC,KPa):未确定 7. 折射率:未确定 8. 闪点(ºC):未确定 9. 比旋光度(º):未确定 10. 自燃点或引燃温度(ºC):未确定 11. 蒸气压(Pa,20ºC):未确定 12. 饱和蒸气压(KPa,20ºC):未确定 13. 燃烧热(KJ/mol):未确定 14. 临界温度(ºC):未确定 15. 临界压力(KPa):未确定 16. 油水(辛醇/水)分配系数的对数值:未确定 17. 爆炸上限(%,V/V):未确定 18. 爆炸下限(%,V/V):未确定 19. 溶解性:未确定 |
个人防护装备 | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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危险品运输编码 | NONH for all modes of transport |
WGK德国 | 3 |
Isolation and characterization of exendin-4, an exendin-3 analogue, from Heloderma suspectum venom. Further evidence for an exendin receptor on dispersed acini from guinea pig pancreas.
J. Biol. Chem. 267 , 7402, (1992) The recent identification in Heloderma horridum venom of exendin-3, a new member of the glucagon superfamily that acts as a pancreatic secretagogue, prompted a search for a similar peptide in Heloderm... |
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Glucagon-like peptide-1 stimulates luteinizing hormone-releasing hormone secretion in a rodent hypothalamic neuronal cell line.
J. Clin. Invest. 101 , 1334-1341, (1998) To examine the influence of the putative satiety factor (GLP-1) on the hypothalamo-pituitary-gonadal axis, we used GT1-7 cells as a model of neuronal luteinizing hormone- releasing hormone (LHRH) rele... |
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Glucagon receptor knockout mice display increased insulin sensitivity and impaired beta-cell function.
Diabetes 55(12) , 3463-9, (2006) In previous studies, glucagon receptor knockout mice (Gcgr(-/-)) display reduced blood glucose and increased glucose tolerance, with hyperglucagonemia and increased levels of glucagon-like peptide (GL... |
MFCD00240170 |