化源商城直购
中文名 | 唑来膦酸 |
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英文名 | zoledronic acid |
中文别名 |
1-羟基-2-(咪唑-1-基)-亚乙基-1,1-二磷酸
[1-羟基-2-(1H-咪唑-1-基)亚乙基]二磷酸一水合物 唑来磷酸 唑来磷酸 |
英文别名 |
zoledronate
Zoledronic acid monohydrate P,P′-[1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene]bisphosphonic acid monohydrate acide [1-hydroxy-2-(1H-imidazol-1-yl)éthane-1,1-diyl]bis(phosphonique) hydrogen [1-hydroxy-2-(1H-imidazol-3-ium-1-yl)-1-phosphonoethyl]phosphonate [1-Hydroxy-2-(1H-imidazol-1-yl)-1,1-ethanediyl]bis(phosphonic acid) Phosphonic acid, [1-hydroxy-2-(1H-imidazol-1-yl)ethylidene]bis- [1-Hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl]bis(phosphonic acid) Zometa,Zomera,Aclasta and Reclast MFCD00867791 [1-Hydroxy-2-(1H-imidazol-1-yl)-ethylidene]bisphosphonic acid [1-Hydroxy-2-(1H-imidazol-1-yl)ethan-1,1-diyl]bis(phosphonsäure) Zoledronic acid Phosphonic acid (P,P'-[1-hydroxy-2-(1H-imidazol-1-yl)ethylidene]bis [1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene]bisphosphonic Acid (1-Hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl)diphosphonic acid 2-(Imidazol-1-yl)-1-hydroxyethane-1,1-diphosphonic Acid [1-hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl]bis(phosphonic acid) monohydrate |
描述 | Zoledronic Acid 是第三代含氮二磷酸盐,能够抑制破骨细胞介导的骨吸收,同时具有抗肿瘤的活性。 |
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相关类别 | |
体外研究 | 唑来膦酸在0.5μM时诱导HGF和HaCaT细胞凋亡,并导致1-5μM的细胞死亡[1]。在治疗24,48和72小时后,唑来膦酸(50,100μM)在CNE-2Z细胞中引起剂量和时间依赖性细胞凋亡。唑来膦酸(50μM)也可以增加ROS水平,ROS可以介导CNE-2Z细胞中Cl-电流的激活。此外,Zoledronic Acid诱导的细胞凋亡和氯离子电流可以通过敲低ClC-3蛋白表达来阻断[2]。 |
参考文献 |
[1]. Scheper M, et al. A novel soft-tissue in vitro model for bisphosphonate-associated osteonecrosis. ibrogenesis Tissue Repair. 2010 Apr 1;3:6. [2]. Wang L, et al. The apoptotic effect of Zoledronic acid on the nasopharyngeal carcinoma cells via ROS mediated chloride channel activation. Clin Exp Pharmacol Physiol. 2018 Jun 8. |
密度 | 2.1±0.1 g/cm3 |
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沸点 | 764.0±70.0 °C at 760 mmHg |
熔点 | 193-2040?C |
分子式 | C5H10N2O7P2 |
分子量 | 272.090 |
闪点 | 415.8±35.7 °C |
精确质量 | 271.996338 |
PSA | 172.73000 |
LogP | -2.28 |
外观性状 | 白色结晶粉末 |
蒸汽压 | 0.0±2.7 mmHg at 25°C |
折射率 | 1.719 |
储存条件 | 室温 |
:β (欧洲) | Xi: Irritant; |
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风险声明 (欧洲) | R21/22 |
安全声明 (欧洲) | 24/25-36/37/39 |
海关编码 | 2933290090 |
~99% 118072-93-8 |
文献:Synthon B.V. Patent: EP2192126 A1, 2010 ; Location in patent: Page/Page column 9 ; |
~% 118072-93-8 |
文献:Letters in Drug Design and Discovery, , vol. 9, # 4 p. 345 - 351 |
~% 118072-93-8 |
文献:Acta Crystallographica Section C: Crystal Structure Communications, , vol. 69, # 3 p. 263 - 266 |
~% 118072-93-8 |
文献:Phosphorus, Sulfur and Silicon and the Related Elements, , vol. 188, # 1-3 p. 39 - 41 |
~% 118072-93-8 |
文献:Russian Journal of General Chemistry, , vol. 82, # 6 p. 1178 - 1179,2 Zhurnal Obshchei Khimii, , vol. 82, # 6 p. 1044 - 1045,2 |
上游产品 4 | |
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下游产品 1 | |
海关编码 | 2933290090 |
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中文概述 | 2933290090. 其他结构含非稠合咪唑环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0% |
申报要素 | 品名, 成分含量, 用途, 乌洛托品请注明外观, 6-己内酰胺请注明外观, 签约日期 |
Summary | 2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |