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Journal of medicinal chemistry

cc彩球网:New series of morpholine and 1, 4-oxazepane derivatives as dopamine D4 receptor ligands: synthesis and 3D-QSAR model

K Audouze, E? Nielsen, D Peters

文献索引:Audouze, Karine; Nielsen, Elsebet stergaard.; Peters, Dan Journal of Medicinal Chemistry, 2004 , vol. 47, # 12 p. 3089 - 3104

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被引用次数: 79

摘要

Since the identification of the dopamine D4 receptor subtype and speculations about its possible involvement in schizophrenia, much work has been put into development of selective D4 ligands. These selective ligands may be effective antipsychotics without extrapyramidal side effects. This work describes the synthesis of a new series of 2, 4- disubstituted morpholines and 2, 4-disubstituted 1, 4-oxazepanes with selectivity for the ...


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